Protein name:
Vacuole membrane protein 1 ;
Alternative:
Transmembrane protein 49 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with TJP1 (By similarity). Interacts with BECN1.
Function:
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion (By similarity). Plays an essential role in formation of cell junctions (By similarity). Plays a role in the initial stages of the autophagic process through its interaction with BECN1.
Subcellular Location:
Endoplasmic reticulum-Golgi intermediate compartment membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Vacuole membrane
Multi-pass membrane protein
Endoplasmic reticulum
Colocalizes with MAP1LC3A and BECN1 in 293T transformed kidney cells.
Protein Attributes:
50:
MAENGTNCDQ | RRGAMSKEQH | NGSFTDPSSV | NEKKRRDREE | RQNIVLWRQP |
100:
LITLQYFSLE | TLVVLKEWTS | KLWHRQSMVV | SFFLLLAALV | ATYYVEGAHQ |
150:
QYVQRIEKQF | LLYAYWIGLG | ILSSVGLGTG | LHTFLLYLGP | HIASVTLAAY |
200:
ECNSVNFPEP | PYPDQIICPD | EEGTEGAISL | WSIISKVRIE | ACMWGIGTAI |
250:
GELPPYFMAR | AARLSGAEPD | DEEYQEFEEM | LEHAETAQDF | ASRAKLAVQK |
300:
LVQKVGFFGI | LACASIPNPL | FDLAGITCGH | FLVPFWTFFG | ATLIGKAIIK |
350:
MHIQKIFVIV | TFSKHIVEQM | VAFIGAVPGI | GPSLQKPFQE | YLEAQRQKLH |
400:
HRSEAGTAQG | ENWLSWTFEK | LVVAMVCYFI | LSIINSMAQS | YAKRIQQRLN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Rat
Human
ELISA Kit for Rat Vacuole membrane protein 1
ELISA Kit for Rat Vacuole membrane protein 1
ELISA Kit for Rat Vacuole membrane protein 1
ELISA Kit for Rat Vacuole membrane protein 1
CLIA Kit for Rat Vacuole membrane protein 1
CLIA Kit for Rat Vacuole membrane protein 1
CLIA Kit for Rat Vacuole membrane protein 1
CLIA Kit for Rat Vacuole membrane protein 1
Polyclonal Antibody for Rat Vacuole membrane protein 1
Polyclonal Antibody for Rat Vacuole membrane protein 1
Polyclonal Antibody for Rat Vacuole membrane protein 1
Polyclonal Antibody for Rat Vacuole membrane protein 1
Monoclonal Antibody for Rat Vacuole membrane protein 1
Monoclonal Antibody for Rat Vacuole membrane protein 1
Monoclonal Antibody for Rat Vacuole membrane protein 1
Monoclonal Antibody for Rat Vacuole membrane protein 1
Protein for Rat Vacuole membrane protein 1
Protein for Rat Vacuole membrane protein 1
Protein for Rat Vacuole membrane protein 1
Protein for Rat Vacuole membrane protein 1
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation."
Dusetti N.J.
,
Jiang Y.
,
Vaccaro M.I.
,
Tomasini R.
,
Azizi Samir A.
,
Calvo E.L.
,
Ropolo A.
,
Fiedler F.
,
Mallo G.V.
,
Dagorn J.-C.
,
Iovanna J.L.
Biochem. Biophys. Res. Commun.290:641-649(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
tissue :
Pancreas .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Prostate .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
5.
"The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells."
Ropolo A.
,
Grasso D.
,
Pardo R.
,
Sacchetti M.L.
,
Archange C.
,
Lo Re A.
,
Seux M.
,
Nowak J.
,
Gonzalez C.D.
,
Iovanna J.L.
,
Vaccaro M.I.
J. Biol. Chem.282:37124-37133(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH BECN1;SUBCELLULAR LOCATION;INDUCTION