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Index > Protein center > Vmp1(Gene name) > Rat
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  • Vmp1 (Gene name),
  • Vacuole membrane protein 1 (Protein name ),  VMP1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Vmp1(Tmem49);
    Protein name:
    Vacuole membrane protein 1;
    Alternative:
    Transmembrane protein 49;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with TJP1 (By similarity). Interacts with BECN1.
    Function:
    Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion (By similarity). Plays an essential role in formation of cell junctions (By similarity). Plays a role in the initial stages of the autophagic process through its interaction with BECN1.
    Subcellular Location:
    Endoplasmic reticulum-Golgi intermediate compartment membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Vacuole membrane Multi-pass membrane protein Endoplasmic reticulum Colocalizes with MAP1LC3A and BECN1 in 293T transformed kidney cells.
    Protein Attributes:
    Sequence length:
    406
    Sequence:
    50:
    MAENGTNCDQ | RRGAMSKEQH | NGSFTDPSSV | NEKKRRDREE | RQNIVLWRQP | 
    100:
    LITLQYFSLE | TLVVLKEWTS | KLWHRQSMVV | SFFLLLAALV | ATYYVEGAHQ | 
    150:
    QYVQRIEKQF | LLYAYWIGLG | ILSSVGLGTG | LHTFLLYLGP | HIASVTLAAY | 
    200:
    ECNSVNFPEP | PYPDQIICPD | EEGTEGAISL | WSIISKVRIE | ACMWGIGTAI | 
    250:
    GELPPYFMAR | AARLSGAEPD | DEEYQEFEEM | LEHAETAQDF | ASRAKLAVQK | 
    300:
    LVQKVGFFGI | LACASIPNPL | FDLAGITCGH | FLVPFWTFFG | ATLIGKAIIK | 
    350:
    MHIQKIFVIV | TFSKHIVEQM | VAFIGAVPGI | GPSLQKPFQE | YLEAQRQKLH | 
    400:
    HRSEAGTAQG | ENWLSWTFEK | LVVAMVCYFI | LSIINSMAQS | YAKRIQQRLN | 
    406:
    SEEKTK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Vacuole membrane protein 1
    Cat.:
    E14852b
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    Packing:
    96T
    ELISA Kit for Rat Vacuole membrane protein 1
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    E14852m
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    96T
    ELISA Kit for Rat Vacuole membrane protein 1
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    E14852r
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    96T
    ELISA Kit for Rat Vacuole membrane protein 1
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    E14852h
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    CLIA Kit for Rat Vacuole membrane protein 1
    Cat.:
    U14852b
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    Packing:
    96T
    CLIA Kit for Rat Vacuole membrane protein 1
    Cat.:
    U14852m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Vacuole membrane protein 1
    Cat.:
    U14852r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Vacuole membrane protein 1
    Cat.:
    U14852h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Rat Vacuole membrane protein 1
    Cat.:
    P14852Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Vacuole membrane protein 1
    Cat.:
    P14852Rb-h
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    40ug/0.2ml
    Polyclonal Antibody for Rat Vacuole membrane protein 1
    Cat.:
    P14852Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Vacuole membrane protein 1
    Monoclonal Antibody for Rat Vacuole membrane protein 1
    Monoclonal Antibody for Rat Vacuole membrane protein 1
    Monoclonal Antibody for Rat Vacuole membrane protein 1
    Monoclonal Antibody for Rat Vacuole membrane protein 1
    Protein for Rat Vacuole membrane protein 1
    Protein for Rat Vacuole membrane protein 1
    Protein for Rat Vacuole membrane protein 1
    Protein for Rat Vacuole membrane protein 1

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    References
    1. 1.
      "Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation."
      Dusetti N.J. , Jiang Y. , Vaccaro M.I. , Tomasini R. , Azizi Samir A. , Calvo E.L. , Ropolo A. , Fiedler F. , Mallo G.V. , Dagorn J.-C. , Iovanna J.L.
      Biochem. Biophys. Res. Commun.290:641-649(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
      tissue: Pancreas.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Prostate.
    3. 3.
      "VMP1 expression correlates with acinar cell cytoplasmic vacuolization in arginine-induced acute pancreatitis."
      Vaccaro M.I. , Grasso D. , Ropolo A. , Iovanna J.L. , Cerquetti M.C.
      Pancreatology3:69-74(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    4. 4.
      "Expression of vacuole membrane protein 1 (VMP1) in spontaneous chronic pancreatitis in the WBN/Kob rat."
      Jiang P.H. , Motoo Y. , Vaccaro M.I. , Iovanna J.L. , Okada G. , Sawabu N.
      Pancreas29:225-230(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    5. 5.
      "The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells."
      Ropolo A. , Grasso D. , Pardo R. , Sacchetti M.L. , Archange C. , Lo Re A. , Seux M. , Nowak J. , Gonzalez C.D. , Iovanna J.L. , Vaccaro M.I.
      J. Biol. Chem.282:37124-37133(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BECN1;SUBCELLULAR LOCATION;INDUCTION
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